20q12 pin

FISH

20q12

Alternate Test Names:
MDS Panel test; Myeloproliferative Disorder (MPD) Panel test

Methodology: FISH

Clinical Significance:
This FISH test detects deletion of 20q12, which is a chromosomal abnormality seen in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This FISH test is frequently utilized in the workup of MDS, which is a heterogeneous group of clonal myeloid stem cell disorders. Deletion of 20q12 as a sole abnormality is associated with a favorable prognosis. When seen with other chromosomal abnormalities, deletion 20q12 is associated with a poor prognosis.

Probe type: Single Color Enumeration

Organ: Blood/Bone Marrow, Body Fluids, Lymph Node / Spleen

Disease State: Acute Myeloid Leukemia (AML) / Myeloid Sarcoma, Myelodysplastic Syndromes

CPT Code(s): 88367 or 88373

Turnaround Time: Within 3-4 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Peripheral blood, Preferred: 3 ml in sodium heparin (green top) / Acceptable: 3 ml in EDTA (purple top) - OR -
• Bone marrow aspirate, Preferred: 1-2 ml in sodium heparin (green top) / Acceptable: 1-2 ml in EDTA (purple top) - OR -
• Fresh tissue in RPMI

Tech Only