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This FISH panel is useful in the identification of a diverse set of specific chromosome alterations associated with various acute myelogenous leukemia (AML) subtypes that are part of the WHO Classification system for hematopoietic tumors. The t(8;21) is found in ~5% of AML and is associated with younger patient age and favorable response to chemotherapy with a high complete remission rate. t(15;17) is the hallmark chromosomal translocation in acute promyelocytic leukemia (APL) and involves the PML and RARA genes. The inv16/t(16;16)(p13;q22) group of leukemias occur in younger patients and this genetic alteration results in fusion of the CBFB gene to the MYH1 gene. This form of AML exhibits monocytic and granulocytic differentiation and a prominent eosinophilic component in the marrow. Monosomy 7/del 7q is found in ~40% of childhood myelodysplastic syndrome (MDS) and ~5% of pediatric AML and is associated with an adverse prognosis in the later. The 11q23 (MLL) rearranged cases of AML is associated with monocytic differentiation and a worse prognosis. Trisomy 8 is one of the most common numerical chromosomal alterations in AML, occurring in ~40% of cases and may portend a worse outcome.
Organ: Blood/Bone Marrow
Disease State: Acute Myeloid Leukemia (AML) / Myeloid Sarcoma
CPT Code(s): 88374x6, 88367 (reference only; CPTs may vary)
Turnaround Time: Within 4-6 business days of receipt
Schedule: Monday - Friday
• Peripheral blood, Preferred: 3 ml in sodium heparin (green top) / Acceptable: 3 ml in EDTA (purple top) - OR - • Bone marrow aspirate, Preferred: 1-2 ml in sodium heparin (green top) / Acceptable: 1-2 ml in EDTA (purple top) - OR - • Fresh tissue in RPMI