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Identifies a cytoplasmic/mitochondrial protein that inhibits apoptosis. Bcl-2 is also overexpressed as a result of the t(14;18) in the majority of follicular lymphomas, and in a significant minority of diffuse large B cell lymphomas of germinal center phenotype. Bcl-2 expression in other B cell neoplasms is not associated with the t(14;18). Bcl-2 expression has been observed in the following lymphomas: DLBCL, FL, small lymphocytic (SLL), mantle cell (MCL), marginal zone (MZL), anaplastic large cell (ALCL) and T-cell (TCL). Synovial sarcomas and some muscle-derived tumors also have been shown to express Bcl-2. Subcellular Localization: Cytoplasmic
Disease State: Anaplastic Large Cell Lymphoma (Systemic or Cutaneous)
CPT Code(s): 88342 or 88341. The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.
Turnaround Time: Within 1-2 business days of receipt
Schedule: Monday - Friday
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR - • 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm