bcl-2 (Clone 124) pin

IHC

bcl-2 (Clone 124)

Alternate Test Names:
BCL2 clone 124

Methodology: IHC

Clinical Significance:
Identifies a cytoplasmic/mitochondrial protein that inhibits apoptosis. Bcl-2 is also overexpressed as a result of the t(14;18) in the majority of follicular lymphomas, and in a significant minority of diffuse large B cell lymphomas of germinal center phenotype. Bcl-2 expression in other B cell neoplasms is not associated with the t(14;18). Bcl-2 expression has been observed in the following lymphomas: DLBCL, FL, small lymphocytic (SLL), mantle cell (MCL), marginal zone (MZL), anaplastic large cell (ALCL) and T-cell (TCL). Synovial sarcomas and some muscle-derived tumors also have been shown to express Bcl-2.

Subcellular Localization: Cytoplasmic

Organ:

Disease State: Anaplastic Large Cell Lymphoma (Systemic or Cutaneous), Diffuse Large B Cell Lymphoma, Follicular Lymphoma, Mantle Cell Lymphoma, T Cell Non-Hodgkin Lymphoma (not otherwise classified)

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm

Tech Only