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bcl-2 (Clone 124) pin


bcl-2 (Clone 124)

Methodology: IHC

Clinical Significance:
Identifies a cytoplasmic/mitochondrial protein that inhibits apoptosis. Bcl-2 is also overexpressed as a result of the t(14;18) in the majority of follicular lymphomas, and in a significant minority of diffuse large B cell lymphomas of germinal center phenotype. Bcl-2 expression in other B cell neoplasms is not associated with the t(14;18). Bcl-2 expression has been observed in the following lymphomas: DLBCL, FL, small lymphocytic (SLL), mantle cell (MCL), marginal zone (MZL), anaplastic large cell (ALCL) and T-cell (TCL). Synovial sarcomas and some muscle-derived tumors also have been shown to express Bcl-2. Subcellular Localization: Cytoplasmic


Disease State: Anaplastic Large Cell Lymphoma (Systemic or Cutaneous)

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR - • 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm