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This sensitive breakapart FISH assay detects any translocation inolving the BCL6 gene but does not specifically distinguish between any of the many different BCL6 translocation partners (e.g., immunoglobulin heavy and light chain genes, the PIM1 gene, and the transferrin receptor gene). Chromosomal translocations involving bcl-6 on 3q27 are one of the most common genetic alterations in B cell non-Hodgkin lymphomas and have been described in up to 35% of diffuse large B cell lymphomas (DLBCLs), follicular lymphomas, and so-called "double-hit" aggressive B cell lymphomas. Detection of translocations involving the bcl-6 gene on 3q27 can be helpful in sub-classifying B cell lymphomas including where folliciluar lymphoma is in the differential and in the evaluation of aggressive B cell lymphomas where Burkitt' lymphoma, atypical Burkitt's, DLBCL, and B cell lymphomas that are intermediate between DLBCL and BL are being considered. Probe type: Dual color breakapart
Organ: Blood/Bone Marrow
Disease State: B Cell Non-Hodgkin Lymphoma (not otherwise classified)
CPT Code(s): 88374 (reference only; CPTs may vary)
Turnaround Time: Within 4-6 business days of receipt
Schedule: Monday - Friday
• Peripheral blood, Preferred: 3 ml in sodium heparin (green top) / Acceptable: 3 ml in EDTA (purple top) - OR - • Bone marrow aspirate, Preferred: 1-2 ml in sodium heparin (green top) / Acceptable: 1-2 ml in EDTA (purple top) - OR - • Fresh tissue in RPMI - OR - • Formalin-fixed, paraffin-embedded tissue (FFPE)