Methodology: IHC

Clinical Significance:
Abnormal nuclear localization of beta catenin generally indicates the presence of a mutation in WNT/APC pathway. Such mutations are characteristic of abdominal fibromatoses. High levels of nuclear beta catenin expression can also be seen in endometrial stromal tumors, synovial sarcomas, solitary fibrous tumors, and a subset of colorectal and endometrial adenocarcinoma. Subcellular Localization: Cytoplasmic and membranous (normal); nuclear (abnormal)

Organ: OB/GYN

Disease State: Spindle Cell Tumors / Sarcoma Subtyping

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR - • 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm