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IHC
Methodology: IHC
Clinical Significance:
Identifies all normal B cells throughout maturation (from immature forms to plasma cells). Bob-1 and Oct-2 are co-expressed in almost all non-Hodgkin lymphomas, plasma cell neoplasms, and nodular lymphocyte predominance lymphomas, but one or both is aberrantly lost in nearly all cases of classical Hodgkin lymphoma.
Subcellular Localization: Nuclear
Organ:
Disease State: B Cell Non-Hodgkin Lymphoma (not otherwise classified)
CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)
Turnaround Time: Within 1-2 business days of receipt
Schedule: Monday - Friday
Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm