Alternate Test Names:
Bob1

Methodology: IHC

Clinical Significance:
Identifies all normal B cells throughout maturation (from immature forms to plasma cells). Bob-1 and Oct-2 are co-expressed in almost all non-Hodgkin lymphomas, plasma cell neoplasms, and nodular lymphocyte predominance lymphomas, but one or both is aberrantly lost in nearly all cases of classical Hodgkin lymphoma.

Subcellular Localization: Nuclear

Organ:

Disease State: B Cell Non-Hodgkin Lymphoma (not otherwise classified), Classical Hodgkin Lymphoma, Nodular Lymphocyte-Predominant Hodgkin Lymphoma

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm