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Breast Multiplex (CK5/14 + P63 + CK7/18), IHC pin


Breast Multiplex (CK5/14 + P63 + CK7/18), IHC

Methodology: IHC

Clinical Significance:
The IHC Breast Multiplex assay is intended for the qualitative identification of Keratin 5/14, p63 protein and Keratin 7/18 by two color immunohistochemistry (IHC). This multiplex assay has two diagnostic applications: 1. Invasive carcinoma versus non-invasive lesions: The presence of myoepithelial cells around suspicious cells nests argues against a diagnosis of invasive carcinoma and can aid in identifying a non-invasive entity, such as carcinoma in situ, atypical ductal hyperplasia (ADH), usual ductal hyperplasia (UDH), and sclerosing adenosis. 2. Usual ductal hyperplasia versus atypical ductal hyperplasia and carcinoma in situ: The presence of staining for Keratin 5 among the luminal cells of a hyperplastic breast lesion can aid in distinguishing usual ductal hyperplasia (typically positive for Keratin 5) from atypical ductal hyperplasia/carcinoma in situ (typically negative for Keratin 5).

Organ: Breast

Disease State: Mesothelioma vs. Adenocarcinoma

CPT Code(s): 88344. The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR - • 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm