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c-kit (CD117) pin


c-kit (CD117)

Methodology: IHC

Clinical Significance:
c-kit, also known as stem cell receptor, is a protein kinase transmembrane receptor that is a marker of gastrointestinal stromal tumors and a mutant form of which is a target of Imatinib therapy. Wild type c-kit expression is present in mast cells, melanocytes, germ cells, glandular epithelium of the breast and salivary gland, and normal interstitial cells of Cajal of the intestine. Subcellular Localization: Membranous

Organ: OB/GYN

Disease State: Spindle Cell Tumors / Sarcoma Subtyping

CPT Code(s): 88342 or 88341. The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR - • 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm