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c-kit (CD117) pin


c-kit (CD117)

Methodology: IHC

Clinical Significance:
c-kit, also known as stem cell receptor, is a protein kinase transmembrane receptor that is a marker of gastrointestinal stromal tumors and a mutant form of which is a target of Imatinib therapy. Wild type c-kit expression is present in mast cells, melanocytes, germ cells, glandular epithelium of the breast and salivary gland, and normal interstitial cells of Cajal of the intestine. Subcellular Localization: Membranous

Organ: OB/GYN

Disease State: Spindle Cell Tumors / Sarcoma Subtyping

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR - • 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm