Methodology: IHC

Clinical Significance:
Identifies the protein product of the gene first discovered in Burkitt’s lymphoma, overexpressed as a consequence of chromosomal translocation involving chromosome 8. Used to screen diffuse large B cell lymphomas to identify those with high-level expression, corresponding to those tumors with a relatively high likelihood of harboring a c-MYC gene rearrangement by FISH. Subcellular Localization: Nuclear

Organ:

Disease State:

CPT Code(s): 88360 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR - • 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm