CD103 & PAX-5 pin


CD103 & PAX-5

Methodology: IHC

Clinical Significance:
CD103, or integrin αE, is preferentially expressed in human intestinal intraepithelial lymphocytes (IELs) and in specific types of lymphoid tumors. The main areas of diagnostic interest are the identification of hairy cell leukemia (HCL, almost always CD103+), and the distinction from marginal zone lymphomas and other potential HCL mimics (usually, but not always, CD103-negative). One other potential use of this antibody is the identification of intraepithelial gastrointestinal T cells (usually CD103+) and enteropathy-associated T cell lymphoma (EATL), a malignancy derived from these T cells, often in the setting of underlying celiac disease.

Due to the the fact that CD103 is not a lineage-specific antigen, PhenoPath's policy is to run the B cell marker PAX-5 in conjunction with all CD103 test orders. Ref: AJCP 139:220-230, 2013

Subcellular Localization: Cytoplasmic and membranous with membranous accentuation

Organ: Blood/Bone Marrow, Colon & Other GI, Lymph Node / Spleen

Disease State: Hairy Cell Leukemia, Marginal Zone/MALT Lymphoma, T Cell Non-Hodgkin Lymphoma (not otherwise classified)

CPT Code(s): 88342 and 88341

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• Minimum of 4 unstained slides cut at 4µm

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