The expression of CD14 by IHC is a useful biomarker for distinguishing neoplasms of monocytic and Langerhans cell origin from other hematolymphoid neoplasms. CD14 is a glycoprotein expressed on mature monocytes, histiocytes/macrophages, Langerhans cells, and to a lesser degree on neutrophils, and is a receptor for bacterial lipopolysaccharide (LPS), thus functioning as an opsonic receptor to facilitate phagocytic uptake.
Subcellular Localization: Membranous and cytoplasmic
Disease State: Acute Myeloid Leukemia (AML) / Myeloid Sarcoma, Langerhans Cell Histiocytosis, Myelodysplastic Syndromes, Myeloproliferative Neoplasms, Including Chronic Myelogenous Leukemia (CML), Spindle Cell Tumors / Sarcoma Subtyping
CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)
Turnaround Time: Within 1-2 business days of receipt
Schedule: Monday - Friday
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm