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The expression of CD14 by IHC is a useful biomarker for distinguishing neoplasms of monocytic and Langerhans cell origin from other hematolymphoid neoplasms. CD14 is a glycoprotein expressed on mature monocytes, histiocytes/macrophages, Langerhans cells, and to a lesser degree on neutrophils, and is a receptor for bacterial lipopolysaccharide (LPS), thus functioning as an opsonic receptor to facilitate phagocytic uptake. Subcellular Localization: Membranous and cytoplasmic
Disease State: Spindle Cell Tumors / Sarcoma Subtyping
CPT Code(s): 88342 or 88341. The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.
Turnaround Time: Within 1-2 business days of receipt
Schedule: Monday - Friday
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR - • 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm