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CD14 pin



Methodology: IHC

Clinical Significance:
The expression of CD14 by IHC is a useful biomarker for distinguishing neoplasms of monocytic and Langerhans cell origin from other hematolymphoid neoplasms. CD14 is a glycoprotein expressed on mature monocytes, histiocytes/macrophages, Langerhans cells, and to a lesser degree on neutrophils, and is a receptor for bacterial lipopolysaccharide (LPS), thus functioning as an opsonic receptor to facilitate phagocytic uptake.

Subcellular Localization: Membranous and cytoplasmic

Organ: Blood/Bone Marrow, Lung, Lymph Node / Spleen, Skin & Mucosa, Soft Tissue

Disease State: Acute Myeloid Leukemia (AML) / Myeloid Sarcoma, Langerhans Cell Histiocytosis, Myelodysplastic Syndromes, Myeloproliferative Neoplasms, Including Chronic Myelogenous Leukemia (CML), Spindle Cell Tumors / Sarcoma Subtyping

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm

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