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A cytoplasmic- and cell surface-associated protein that is strongly expressed by granulocytes at the promyelocyte and later stages, and is expressed at lower levels on monocytes/histiocytes. CD15 is aberrantly coexpressed by myeloid blasts in a subset of myeloid stem cell neoplasms. In addition, CD15 is expressed in a membrane and/or Golgi pattern in the majority of cases of classical Hodgkin lymphoma. Finally, CD15 is expressed by a subset of normal and neoplastic epithelia.
Subcellular Localization: Membranous
Disease State: Classical Hodgkin Lymphoma
CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)
Turnaround Time: Within 1-2 business days of receipt
Schedule: Monday - Friday
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm