Methodology: IHC

Clinical Significance:
A cytoplasmic- and cell surface-associated protein that is strongly expressed by granulocytes at the promyelocyte and later stages, and is expressed at lower levels on monocytes/histiocytes. CD15 is aberrantly coexpressed by myeloid blasts in a subset of myeloid stem cell neoplasms. In addition, CD15 is expressed in a membrane and/or Golgi pattern in the majority of cases of classical Hodgkin lymphoma. Finally, CD15 is expressed by a subset of normal and neoplastic epithelia.

Subcellular Localization: Membranous

Organ:

Disease State: Classical Hodgkin Lymphoma

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm