Methodology: IHC

Clinical Significance:
CD1a is a cell surface-associated protein expressed at the "dual-positive" stage of T cell development, which is the stage at which CD4 and CD8 are coexpressed on immature T cells in the thymus. CD1a is expressed on a subset of precursor T lymphoblastic leukemias/lymphomas corresponding to this stage of T cell development. CD1a is also expressed on the great majority of normal and neoplastic Langerhans cells. Subcellular Localization: Membranous and cytoplasmic

Organ:

Disease State: Precursor T-Lymphoblastic Lymphoma/Leukemia (T-ALL)

CPT Code(s): 88342 or 88341. The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR - • 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm