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CD20 pin



Methodology: IHC

Clinical Significance:
CD20 is a cell surface-associated protein expressed during the middle to later stages of B cell maturation in the bone marrow, and on all normal mature B cells. CD20 ceases to be expressed at the terminal differentiation of B cells to plasma cells. CD20 is expressed on the great majority of mature B cell neoplasms, and on a significant subset of immature B cell neoplasms, but only rarely on plasmacytic neoplasms. CD20 is the target of the therapeutic antibody known as Rituxan. Subcellular Localization: Membranous

Organ: Blood/Bone Marrow

Disease State: Large Cell Undifferentiated Malignant Neoplams

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR - • 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm