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CD25 (IL-2Rα) pin


CD25 (IL-2Rα)

Methodology: IHC

Clinical Significance:
CD25 (IL-2Rα) is a cell surface-associated protein that is the receptor for interleukin-2. CD25 is expressed on a significant subset of activated T cells, and tends to be strongly expressed on the neoplastic T cells of adult T cell leukemia/lymphoma and anaplastic large cell lymphoma. CD25 is also coexpressed on a subset of B cell neoplasms, most notably hairy cell leukemia. Aberrant CD25 expression on mast cells is an important immunophenotypic clue to the diagnosis of systemic mastocytosis. Subcellular Localization: Membranous


Disease State: Anaplastic Large Cell Lymphoma (Systemic or Cutaneous)

CPT Code(s): 88342 or 88341. The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR - • 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm