CD3 pin

IHC

CD3

Methodology: IHC

Clinical Significance:
CD3 is a multimeric cell surface-associated protein expressed in T cells in association with the T cell antigen receptor. Cell surface CD3 begins to be expressed during T cell development in the thymus, and is expressed throughout later T cell maturation. CD3 is aberrantly decreased in a subset of T cell neoplasms. NK cells do not express surface CD3, but do express the epsilon chain of CD3 in the cytoplasm.

Subcellular Localization: Membranous

Organ:

Disease State: Angioimmunoblastic T Cell Lymphoma, NK/T Cell Lymphoma, Nasal Type, Peripheral T Cell Lymphoma, NOS (of Large Cell Type)

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm

Tech Only