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CD3 is a multimeric cell surface-associated protein expressed in T cells in association with the T cell antigen receptor. Cell surface CD3 begins to be expressed during T cell development in the thymus, and is expressed throughout later T cell maturation. CD3 is aberrantly decreased in a subset of T cell neoplasms. NK cells do not express surface CD3, but do express the epsilon chain of CD3 in the cytoplasm.
Subcellular Localization: Membranous
CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)
Turnaround Time: Within 1-2 business days of receipt
Schedule: Monday - Friday
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm