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CD30 (K-1 antigen) pin


CD30 (K-1 antigen)

Methodology: IHC

Clinical Significance:
CD30 is a cytoplasmic- and cell surface-associated protein expressed by a significant subset of activated B cells and T cells. CD30 is expressed at variable levels by Reed-Sternberg cells and variants in the majority of cases of classical Hodgkin lymphoma. Among the non-Hodgkin lymphomas, CD30 is strongly and uniformly expressed in anaplastic large cell lymphoma, and at variable levels in a significant subset of other non-Hodgkin lymphomas, particularly those of large cell type. CD30 is also expressed by embryonal carcinomas.

Subcellular Localization: Membranous and cytoplasmic

Organ: Genitourinary, OB/GYN, Ovary, Testis

Disease State: Anaplastic Large Cell Lymphoma (Systemic or Cutaneous), Classical Hodgkin Lymphoma, Germ Cell Tumors, Large Cell Undifferentiated Malignant Neoplams, Mastocytosis

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm

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