Methodology: IHC

Clinical Significance:
CD34 is a transmembrane sialomucin expressed in lymphohematopoietic stem and progenitor cells, as well as endothelial cells. It is also a marker of a unique subset of mesenchymal tumors (e.g., solitary fibrous tumor, dermatofibrosarcoma protuberans, epithelioid sarcoma, gastrointestinal stromal tumor, etc.).

Subcellular Localization: Membranous

Organ: Colon & Other GI, Liver, Skin & Mucosa

Disease State: Hepatocellular Carcinoma, Large Cell Undifferentiated Malignant Neoplams, Spindle Cell Tumors / Sarcoma Subtyping

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm