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CD35 is a follicular dendritic cell surface-associated protein. CD35 expression is present in a sharply defined FDC meshwork in many follicular lymphomas (e.g. centroblastic/centrocytic lymphoma) and a loose, ill-defined FDC meshwork of varying size in some diffuse lymphomas (most constantly in centrocytic lymphomas). A nodular form of lymphocyte-predominant type of Hodgkin disease (LPHD) is the only category of Hodgkin disease that has a characteristic meshwork of FDC. CD35 is also expressed on monocytes, neutrophils, and B cells. Subcellular Localization: Membranous
Disease State: Nodular Lymphocyte-Predominant Hodgkin Lymphoma
CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)
Turnaround Time: Within 1-2 business days of receipt
Schedule: Monday - Friday
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR - • 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm