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CD38 pin

IHC

CD38

Methodology: IHC

Clinical Significance:
CD38 is a 46 kDa type II transmembrane glycoprotein with a short N-terminal cytoplasmic tail (20 amino acids) and a long extracellular domain (256 amino acids). CD38 is expressed by a variety of leukocytes, including plasma cells (which show the highest levels of expression), immature and mature B and T cells, NK cells, monocytes, macrophages, and myeloid progenitors. It has enzymatic activity as a cyclic ADP ribose hydrolase, which contributes to the regulation of intracellular calcium. The ligand of CD38 is CD31. In mature B cells, CD38 expression is induced once naive B lymphocytes are activated, reaches a first peak when B cells enter the germinal center, decreases during centrocyte/centroblast differentiation, is completely absent in memory B cells, and reaches its maximum levels as B cells terminally differentiate to plasma cells. In HIV, increased T-cell CD38 expression is associated with disease progression. CD38 expression has been described in some non-hematopoietic tissues. Subcellular Localization: Membranous

Organ: Blood/Bone Marrow

Disease State: B Cell NHL with Plasmacytoid Differentiation

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR - • 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm