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CD38 pin

IHC

CD38

Methodology: IHC

Clinical Significance:
CD38 is a 46 kDa type II transmembrane glycoprotein with a short N-terminal cytoplasmic tail (20 amino acids) and a long extracellular domain (256 amino acids). CD38 is expressed by a variety of leukocytes, including plasma cells (which show the highest levels of expression), immature and mature B and T cells, NK cells, monocytes, macrophages, and myeloid progenitors. It has enzymatic activity as a cyclic ADP ribose hydrolase, which contributes to the regulation of intracellular calcium. The ligand of CD38 is CD31. In mature B cells, CD38 expression is induced once naive B lymphocytes are activated, reaches a first peak when B cells enter the germinal center, decreases during centrocyte/centroblast differentiation, is completely absent in memory B cells, and reaches its maximum levels as B cells terminally differentiate to plasma cells. In HIV, increased T-cell CD38 expression is associated with disease progression. CD38 expression has been described in some non-hematopoietic tissues. Subcellular Localization: Membranous

Organ: Blood/Bone Marrow

Disease State: B Cell NHL with Plasmacytoid Differentiation

CPT Code(s): 88342 or 88341. The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR - • 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm