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CD45 pin



Methodology: IHC

Clinical Significance:
Identifies leukocyte common antigen (LCA), a family of cell surface proteins expressed at variable levels in all normal hematopoietic cells, with the exception of erythroid cells that have matured beyond the proerythroblasts stage. A variety of hematopoietic neoplasms show aberrant increases or decreases in the level of CD45 expression. Aberrant loss of CD45 is seen in a subset of precursor B-lymphoblastic leukemias, in the majority of multiple myelomas, and in nearly all cases of classical Hodgkin's lymphoma (on Reed-Sternberg cells and variants). Subcellular Localization: Membranous


Disease State: Large Cell Undifferentiated Malignant Neoplams

CPT Code(s): 88342 or 88341. The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR - • 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm