Identifies leukocyte common antigen (LCA), a family of cell surface proteins expressed at variable levels in all normal hematopoietic cells, with the exception of erythroid cells that have matured beyond the proerythroblasts stage. A variety of hematopoietic neoplasms show aberrant increases or decreases in the level of CD45 expression. Aberrant loss of CD45 is seen in a subset of precursor B-lymphoblastic leukemias, in the majority of multiple myelomas, and in nearly all cases of classical Hodgkin's lymphoma (on Reed-Sternberg cells and variants).
Subcellular Localization: Membranous
Disease State: Angioimmunoblastic T Cell Lymphoma, Classical Hodgkin Lymphoma, Large Cell Undifferentiated Malignant Neoplams, NK/T Cell Lymphoma, Nasal Type, Nodular Lymphocyte-Predominant Hodgkin Lymphoma, Peripheral T Cell Lymphoma, NOS (of Large Cell Type)
CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)
Turnaround Time: Within 1-2 business days of receipt
Schedule: Monday - Friday
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm