CD5 pin

IHC

CD5

Methodology: IHC

Clinical Significance:
CD5 is a cell surface-associated protein expressed in mature and immature T cells, but not in NK cells. CD5 is aberrantly decreased in a subset of T cell neoplasms. CD5 shows characteristic aberrant expression by two B cell neoplasms, chronic lymphocytic leukemia/small lymphocytic lymphoma and mantle cell lymphoma, although a small number of other B cell neoplasms can show low-level coexpression of CD5.

Subcellular Localization: Membranous

Organ:

Disease State: Angioimmunoblastic T Cell Lymphoma, Chronic Lymphocytic Leukemia / Small Lymphocytic Lymphoma (CLL/SLL), Mantle Cell Lymphoma, Peripheral T Cell Lymphoma, NOS (of Large Cell Type)

CPT Code(s): 88342 or 88341

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm

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