Methodology: IHC

Clinical Significance:
CD57 is a cell surface-associated protein expressed on a subset of activated T cells, including so-called large granular lymphocytes, and neoplasms derived from these cells. CD57 is also expressed on a variety of neural structures. Identification of CD57-positive cells is of value in positively identifying lymphocyte-predominant Hodgkin lymphoma.

Subcellular Localization: Membranous

Organ:

Disease State: Nodular Lymphocyte-Predominant Hodgkin Lymphoma, Spindle Cell Tumors / Sarcoma Subtyping

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm