CDH17 pin



Alternate Test Names:
Cadherin 17
Liver-Intestine Cadherin
human peptide transporter 1

Methodology: IHC

Clinical Significance:
Cadherin 17 is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption. Cadherin 17 is expressed in the epithelial cells of embryonic and adult small intestine, colon, and pancreatic ducts. It has also been reported to be frequently expressed in adenocarcinomas arising in the gastrointestinal tract and pancreas. Owing to its restricted expression in these groups of tumors, cadherin 17 can be a useful immunohistochemical marker for assisting in distinguishing these neoplasms from other malignancies.

The performance characteristics of this antibody have been established within the context of carcinomas arising at different primary sites. This anti-cadherin 17 antibody displays a sensitivity of 95% and a specificity of 95% for colorectal adenocarcinoma.

Subcellular Localization: predominantly membranous with a smaller cytoplasmic component

Organ: Colon & Other GI

Disease State: Adenocarcinoma, Carcinomas of Unknown Primary, Metastatic Carcinoma

CPT Code(s): 88342 or 88341

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm

Tech Only