Alternate Test Names:
Cdx2-D

Methodology: IHC

Clinical Significance:
CDX2 is an intestinal-specific transcription factor, highly expressed in colorectal adenocarcinomas, with a sensitivity > 95%, and also expressed, at lower levels, and with a lower sensitivty, in the vast majority of non-colorectal GI carcinomas, i.e., those primary to the pancreatobiliary tract and stomach. CDX2 is also expressed in neuroendocrine carcinomas of the GI tract.

Subcellular Localization: Nuclear

Organ: Colon & Other GI, Liver, Pancreas

Disease State: Carcinomas of Unknown Primary

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm