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Partial hydatidiform moles have defined histologic abnormalities including dual discrete populations of villi, circumferential mild trophoblastic hyperplasia, trophoblastic inclusions, scalloping of villi, and cistern formation. Nonetheless, morphologic features alone may not be sufficient to confirm the diagnosis of partial hydatidiform mole in some cases, particularly those in the early first trimester. Furthermore, there is significant inter- and intra-observer variability in the diagnosis of hydatidiform mole, with significant problems in differentiating partial hydatidiform moles from hydropic spontaneous abortions. In this assay, the CEP17 probe is used for analysis and interpretation of ploidy status. Identification of triploidy by CEP17 FISH helps to confirm the diagnosis of partial hydatidiform mole and can be used to separate partial hydatidiform moles from complete hydatidiform moles and hydropic products of conception. Probe type: Enumeration (single-color)
Disease State: Molar Pregnancy
CPT Code(s): 88367 or 88373 (reference only; CPTs may vary)
Turnaround Time: Within 4-6 business days of receipt
Schedule: Monday - Friday
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR - • Minimum of 5 unstained slide cut at 4µm for each test requested plus 2 unstained slides cut at 6µm