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This FISH test detects Trisomy 8, which is a chromosomal abnormality seen in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This FISH test is frequently utilized in the workup of MDS, which is a heterogeneous group of clonal myeloid stem cell disorders. Trisomy 8 as a sole abnormality is associated with an intermediate prognosis. Probe type: Single color enumeration
Organ: Blood/Bone Marrow
Disease State: Acute Myeloid Leukemia (AML) / Myeloid Sarcoma
CPT Code(s): 88367 or 88373 (reference only; CPTs may vary)
Turnaround Time: Within 4-6 business days of receipt
Schedule: Monday - Friday
• Peripheral blood, Preferred: 3 ml in sodium heparin (green top) / Acceptable: 3 ml in EDTA (purple top) - OR - • Bone marrow aspirate, Preferred: 1-2 ml in sodium heparin (green top) / Acceptable: 1-2 ml in EDTA (purple top) - OR - • Fresh tissue in RPMI