Methodology: IHC

Clinical Significance:
Identifies a protein unique to the dense core granules of neuroendocrine cells and tumors. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, but not as good a marker of high-grade neurendocrine carcinomas as synaptophysin. Subcellular Localization: Cytoplasmic, often with a granular pattern

Organ: Colon & Other GI

Disease State: Carcinomas of Unknown Primary

CPT Code(s): 88342 or 88341. The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR - • 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm