Alternate Test Names:
PHE5

Methodology: IHC

Clinical Significance:
Identifies a protein unique to the dense core granules of neuroendocrine cells and tumors. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, but not as good a marker of high-grade neurendocrine carcinomas as synaptophysin.

Subcellular Localization: Cytoplasmic, often with a granular pattern

Organ: Colon & Other GI, Pancreas

Disease State: Carcinomas of Unknown Primary

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm