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Clusterin pin



Methodology: IHC

Clinical Significance:
Identifies a heterodimeric protein associated with clearance of cell debris and apoptosis. It is expressed in diffuse large B-cell lymphomas (DLBCL), T-cell rich large B-cell lymphoma, Hodgkin lymphoma, as well as various carcinomas. Clusterin has proven to be an effective tool in the differentiation of anaplastic large cell lymphoma (ALCL) from peripheral T cell lymphoma (PTCL), NOS. Subcellular Localization: Cytoplasmic, in a granular diffuse and/or a Golgi pattern


Disease State: Anaplastic Large Cell Lymphoma (Systemic or Cutaneous)

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR - • 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm