Methodology: IHC

Clinical Significance:
CXCL13 is a chemokine that is a relatively specific marker of follicular helper T cells (TFH cells), the presumed cell of origin in angioimmunblastic T cell lymphoma and, to a lesser extent, other peripheral T cell lymphomas.  Importantly, CXCL13 is a less sensitive but more specific marker of TFH cells than CD10, bcl-6, or PD-1.    By immunohistochemistry, CXCL13 shows granular cytoplasmic reactivity in well-fixed FFPE, but may yield false negative results in suboptimally fixed FFPE. Subcellular Localization: Cytoplasmic (typically granular)

Organ: Blood/Bone Marrow

Disease State: Angioimmunoblastic T Cell Lymphoma

CPT Code(s): 88342 or 88341. The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR - • 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm