Methodology: IHC

Clinical Significance:
Identifies E-cadherin, a transmembrane protein the function of which is cell-cell adhesion. Lobular carcinomas of the breast can be distinguished from ductal carcinomas by the presence in the former of genetic or epigenetic changes affecting the E-cadherin gene resulting in loss, or profound reduction, of expression of E-cadherin protein. Subcellular Localization: Membranous

Organ: Breast

Disease State: Breast Cancer

CPT Code(s): 88342 or 88341. The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR - • 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm