Methodology: IHC

Clinical Significance:
Identifies E-cadherin, a transmembrane protein the function of which is cell-cell adhesion. Lobular carcinomas of the breast can be distinguished from ductal carcinomas by the presence in the former of genetic or epigenetic changes affecting the E-cadherin gene resulting in loss, or profound reduction, of expression of E-cadherin protein. Subcellular Localization: Membranous

Organ: Breast

Disease State: Breast Cancer

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR - • 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm