EBV-LMP pin

IHC

EBV-LMP

Methodology: IHC

Clinical Significance:
Identifies EBV LMP-1 (latent membrane protein-1). EBV-LMP is a cell surface-associated protein encoded by the EBV genome and expressed by a subset of EBV-infected B cells, more commonly in tonsils than in lymph nodes of EBV-infected individuals. LMP-1 is a much less sensitive marker of EBV infection than EBER1 mRNA; the latter is detected by in situ hybridization.

Subcellular Localization: Membranous

Organ:

Disease State: Identification of Organisms, Post-Transplant Lymphoproliferative Disorders

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm

Tech Only