EGFR pin

IHC

EGFR

Methodology: IHC

Clinical Significance:
Identifies epidermal growth factor receptor (EGFR), a transmembrane protein expressed by a subset of carcinomas and other tumors. EGFR is the target of small molecules such as gefitinib and erolitinib, as well as humanized monoclonal antibodies such as cetuximab. Alterations in copy numbers of EGFR can be detected by FISH and mutations of EGFR gene can be detected by PCR.

Subcellular Localization: Membranous

Organ: Colon & Other GI, Lung

Disease State: Non Small Cell Lung Carcinoma (NSCLC)

CPT Code(s): 88360

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm

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