EGFR/CEP7 pin

FISH

EGFR/CEP7

Methodology: FISH

Clinical Significance:
EGFR gene amplification has been reported in a subset of colorectal adenocarcinomas, lung non-small cell carcinomas, and glioblastoma multiforme. Amplification the EGFR gene can often result in overexpression of epidermal growth factor and may contribute to tumorigenesis. With the availability of anti-EGFR monoclonal antibody therapy and small molecular EGFR inhibitors, assessment of EGFR gene amplification may be warranted in some tumors to predict those that may respond to anti-EGFR therapy. This FISH assay uses the established method described by Capuzzo et al., to evaluate tumors for EGFR high polysomy and amplification.

Probe type: Dual color enumeration

Organ: Lung

Disease State: Adenocarcinoma, Non Small Cell Lung Carcinoma (NSCLC)

CPT Code(s): 88374

Turnaround Time: Within 3-4 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded tissue block or cell block - OR -
• Minimum of 5 unstained slide cut at 4µm for each test requested