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Methodology: FISH

Clinical Significance:
EGFR gene amplification has been reported in a subset of colorectal adenocarcinomas, lung non-small cell carcinomas, and glioblastoma multiforme. Amplification the EGFR gene can often result in overexpression of epidermal growth factor and may contribute to tumorigenesis. With the availability of anti-EGFR monoclonal antibody therapy and small molecular EGFR inhibitors, assessment of EGFR gene amplification may be warranted in some tumors to predict those that may respond to anti-EGFR therapy. This FISH assay uses the established method described by Capuzzo et al., to evaluate tumors for EGFR high polysomy and amplification. Probe type: Dual color enumeration

Organ: Lung

Disease State: Mesothelioma vs. Adenocarcinoma

CPT Code(s): 88374 (reference only; CPTs may vary)

Turnaround Time: Within 4-6 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded tissue block or cell block - OR - • Minimum of 5 unstained slide cut at 4µm for each test requested