EGR1 (5q31/5p15.5) pin

FISH

EGR1 (5q31/5p15.5)

Alternate Test Names:
5q31/5p15.5
MDS Panel test
AML Panel test

Methodology: FISH

Clinical Significance:
This FISH probe set detects deletion 5q31 and monosomy 5, which are chromosomal abnormalities seen in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This FISH test is frequently utilized in the workup of MDS, which is a heterogeneous group of clonal myeloid stem cell disorders. Deletion of 5q31 is associated with a favorable prognosis while monosomy 5 is associated with a poor prognosis. Patients with deletion 5q31 are eligible for Revlimid® (lenalidomide) therapy.

Probe type: Dual color enumeration

Organ: Blood/Bone Marrow, Body Fluids, Lymph Node / Spleen

Disease State: Acute Myeloid Leukemia (AML) / Myeloid Sarcoma, Myelodysplastic Syndromes

CPT Code(s): 88374

Turnaround Time: Within 3-4 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Peripheral blood, Preferred: 3 ml in sodium heparin (green top) / Acceptable: 3 ml in EDTA (purple top) - OR -
• Bone marrow aspirate, Preferred: 1-2 ml in sodium heparin (green top) / Acceptable: 1-2 ml in EDTA (purple top) - OR -
• Fresh tissue in RPMI

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