Alternate Test Names:
Epithelial Membrane Antigen

Methodology: IHC

Clinical Significance:
Identifies: Epithelial membrane protein (EMA), a transmembrane glycoprotein encoded by the MUC1 gene. Expression of EMA can assist in the identification of metastatic v. primary cancers in the liver, nerve sheath tumors, meningioma, anaplastic large cell lymphoma, and other tumors.

Subcellular Localization: Membranous

Organ:

Disease State: Anaplastic Large Cell Lymphoma (Systemic or Cutaneous), Large Cell Undifferentiated Malignant Neoplams, Nodular Lymphocyte-Predominant Hodgkin Lymphoma

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm