Methodology: IHC

Clinical Significance:
ERG is a member of the ETS transcription factor gene family, whose members also include FLI1 and ETS1. It is strongly  expressed in endothelial cells and is a highly sensitive and specific marker of vascular neoplasms. Amongst carcinomas, expression of ERG is highly restricted to a subset (40-50%) of prostatic adenocarcinomas. (Miettinen M et al., Am J Surg Pathol. 35:432-41, 2011; Yaskiv O et al., Am J Clin Pathol 138:803-10, 2012). Subcellular Localization: Nuclear

Organ: Prostate

Disease State: Spindle Cell Tumors / Sarcoma Subtyping

CPT Code(s): 88342 or 88341. The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR - • 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm