Methodology: IHC

Clinical Significance:
ERG is a member of the ETS transcription factor gene family, whose members also include FLI1 and ETS1. It is strongly expressed in endothelial cells and is a highly sensitive and specific marker of vascular neoplasms. Amongst carcinomas, expression of ERG is highly restricted to a subset (40-50%) of prostatic adenocarcinomas. (Miettinen M et al., Am J Surg Pathol. 35:432-41, 2011; Yaskiv O et al., Am J Clin Pathol 138:803-10, 2012).

Subcellular Localization: Nuclear

Organ: Prostate, Soft Tissue

Disease State: Spindle Cell Tumors / Sarcoma Subtyping

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm