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The main clinical indication for FOXP3 IHC is expected to be immunophenotyping of tumor infiltrating lymphocytes (TILs) in human tumors. However, unforeseen clinical indications cannot be excluded. FOXP3 is a relatively specific marker of regulatory T cells (Tregs) which normally function to limit T cell-driven immune responses. Tregs are also involved in the immune evasion mechanisms promoted by cancer. Studies on several types of cancer suggested that high levels of Treg infiltration of the tumor bed are associated with poor clinical outcome (Martin F et al. 2010. Oncogene). In addition to FOXP3 expression in the tissues noted below, FOXP3 may be seen in the tumor infiltrating T cells in any type of human tomor. Subcellular Localization: Nuclear
Organ: Blood/Bone Marrow
Disease State: T Cell Non-Hodgkin Lymphoma (not otherwise classified)
CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)
Turnaround Time: Within 1-2 business days of receipt
Schedule: Monday - Friday
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR - • 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm