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Low-grade fibromyxoid sarcoma (LGFMS) is an indolent, late-metastasizing malignant soft-tissue tumor that is often mistaken for either benign or more malignant tumor types. Rearrangement of the FUS gene has been seen in these tumors, and can be used to aid in diagnosis. The FUS (fused in sarcoma) Breakapart probe is designed to detect rearrangement of the FUS gene on the short arm of chromosome 16 (16p11). The FUS gene encodes a multi-functional protein involved in, among other things, transcriptional activation and RNA binding. It is a member of the TET family of proteins that also includes EWS.
Organ: Soft Tissue
Disease State: Spindle Cell Tumors / Sarcoma Subtyping
CPT Code(s): 88374. The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.
Turnaround Time: Within 4-6 business days of receipt
Schedule: Monday - Friday
• Formalin-fixed, paraffin-embedded tissue block or cell block - OR - • Minimum of 5 unstained slide cut at 4µm for each test requested