Methodology: IHC

Clinical Significance:
Identifies: GCET1, a cytoplasmic protein that is relatively specific for normal germinal center B cells and germinal center-derived B cell neoplasms, including follicular lymphoma, Burkitt lymphoma, a subset of diffuse large B cell lymphoma (DLBCL), and nodular lymphocyte predominant Hodgkin lymphoma. GCET is also used as part of a panel of markers in immunohistochemical distinction of germinal center-derived DLBCL from non-germinal center-derived DLBCL. Subcellular Localization: Cytoplasmic (secretory), granular, with frequent Golgi staining

Organ: Genitourinary Tumors

Disease State: Diffuse Large B Cell Lymphoma

CPT Code(s): 88342 or 88341. The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR - • 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm