Alternate Test Names:
GCET-1
Germinal Center B-Cell-Expressed Transcript-1

Methodology: IHC

Clinical Significance:
Identifies: GCET1, a cytoplasmic protein that is relatively specific for normal germinal center B cells and germinal center-derived B cell neoplasms, including follicular lymphoma, Burkitt lymphoma, a subset of diffuse large B cell lymphoma (DLBCL), and nodular lymphocyte predominant Hodgkin lymphoma. GCET is also used as part of a panel of markers in immunohistochemical distinction of germinal center-derived DLBCL from non-germinal center-derived DLBCL.

Subcellular Localization: Cytoplasmic (secretory), granular, with frequent Golgi staining

Organ: Genitourinary, Ovary, Testis

Disease State: Diffuse Large B Cell Lymphoma, Germ Cell Tumors

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm