Alternate Test Names:
GPC-3

Methodology: IHC

Clinical Significance:
Identifies: Glypican-3, a heparan sulfate proteoglycan that is a reliable marker for hepatocellular carcinoma, with a sensitivity and specificity exceeding both alpha-fetoprotein and HepPar1. Glypican-3 is also a marker of yolk sac tumors in the context of other germ cell neoplasms.

Subcellular Localization: Cytoplasmic, granular

Organ: Genitourinary, Liver, OB/GYN, Ovary, Testis

Disease State: Germ Cell Tumors, Hepatocellular Carcinoma

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm