Methodology: IHC

Clinical Significance:
Identifies: Glypican-3, a heparan sulfate proteoglycan that is a reliable marker for hepatocellular carcinoma, with a sensitivity and specificity exceeding both alpha-fetoprotein and HepPar1. Glypican-3 is also a marker of yolk sac tumors in the context of other germ cell neoplasms. Subcellular Localization: Cytoplasmic, granular

Organ: OB/GYN

Disease State: Germ Cell Tumors

CPT Code(s): 88342 or 88341. The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR - • 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm