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H3K27me3 pin



Methodology: IHC

Clinical Significance:
This antibody is used for the identification of malignant peripheral nerve sheet tumors (MPNST), approximately 50% of which show complete loss of expression of this nuclear protein. This loss of expression is highly specific to MPNST, and can help distinguish it from other sarcomas and spindle cell melanomas. Subcellular Localization: Nuclear (Loss of expression)

Organ: Soft Tissue

Disease State: Spindle Cell Tumors / Sarcoma Subtyping

CPT Code(s): 88342 or 88341. The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Turnaround Time: Within 1-2 business days of receipt


Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR - • 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm