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Identifies: Carbamoyl phosphate synthetase 1, a mitochondrial protein present in hepatocytes and hepatocellular carcinoma. When used as part of a panel of other markers, HepPar1 is useful in distinguishing hepatocellular carcinoma from cholangiocarcinoma and metastatic carcinomas to the liver. However, carbamoyl phosphate synthetase 1 is also expressed in a subset of gastric carcinomas as well as ‘hepatoid’ carcinomas of various organs. Subcellular Localization: Cytoplasmic, granular
Disease State: Carcinomas of Unknown Primary
CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)
Turnaround Time: Within 1-2 business days of receipt
Schedule: Monday - Friday
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR - • 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm