Methodology: IHC

Clinical Significance:
Identifies: Carbamoyl phosphate synthetase 1, a mitochondrial protein present in hepatocytes and hepatocellular carcinoma. When used as part of a panel of other markers, HepPar1 is useful in distinguishing hepatocellular carcinoma from cholangiocarcinoma and metastatic carcinomas to the liver. However, carbamoyl phosphate synthetase 1 is also expressed in a subset of gastric carcinomas as well as ‘hepatoid’ carcinomas of various organs. Subcellular Localization: Cytoplasmic, granular

Organ: Liver

Disease State: Carcinomas of Unknown Primary

CPT Code(s): 88342 or 88341. The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR - • 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm