Alternate Test Names:
GCET2, GCAT2, GCSAM

Methodology: IHC

Clinical Significance:
HGAL - also known as GCET2, GCAT2, and GCSAM – is a cytoplasmic protein expressed by benign and neoplastic follicle center (germinal center)-derived B cells. As part of a panel of IHC antibodies, the HGAL antibody is useful to distinguish follicle center-derived B cell non-Hodgkin lymphoma (B-NHL) from other B cell proliferations.


Subcellular Localization: Cytoplasmic

Organ: Lymph Node / Spleen

Disease State: Burkitt's Lymphoma, Diffuse Large B Cell Lymphoma, Follicular Lymphoma

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm