Alternate Test Names:
Human Herpes Virus 8
KSHV
HHV-8

Methodology: IHC

Clinical Significance:
Identifies: HHV8 latent nuclear antigen, or LANA, a nuclear protein expressed by cells infected with HHV8. It is expressed in both Kaposi's sarcoma as well as HHV8-associated lymphoproliferative disorders, including primary effusion lymphomas and multicentric Castleman's disease.

Subcellular Localization: Nuclear positivity with speckled staining pattern

Organ:

Disease State: HIV-Associated Lymphoma, Identification of Organisms, Post-Transplant Lymphoproliferative Disorders

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm