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Hydatidiform Mole Evaluation (Molar Pregnancy) pin


Hydatidiform Mole Evaluation (Molar Pregnancy)

Methodology: FISH

Clinical Significance:
p57kip2 is a paternally imprinted, maternally expressed gene that is not expressed in the cytotrophoblasts of complete moles (which are of paternal origin only). It is positive in both partial moles and normal hydropic villi. In addition, complete moles are characterized by high Ki-67-defined proliferative index in the cytotrophoblasts.  Further distinction of partial moles from hydropic normal villi can be made by identifying the triploid nature of incomplete moles. This can be accomplished by fluorescence in situ hybridization studies using a chromosome 17 probe to ascertain ploidy. It should be noted that these mole ploidy studies are best interpreted in conjunction with morphology for the evaluation of both complete and partial moles.

Organ: OB/GYN

Disease State: Molar Pregnancy

CPT Code(s): 88342; 88360; 88367; 88323. The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Turnaround Time: Within 4-6 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR - • Minimum of 5 unstained slide cut at 4µm for each test requested plus 2 unstained slides cut at 6µm