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IGH Breakapart pin

FISH

IGH Breakapart

Methodology: FISH

Clinical Significance:
This sensitive breakapart FISH assay detects any translocation involving the IGH gene, although it does not identify the gene with which it is partnered. Many different translocation partners for the IGH gene have been identified in human B cell lymphoma including BCL2 in follicular lymphomas resulting in the t(14;18), CCND1 in mantle cell lymphoma resulting in the t(11;14), MYC in Burkitt's lymphoma resulting in the t(8;14), MALT1 in malt lymphoma resulting in the t(14;18), and CMAF and FGFR3 in myeloma reulting in the t(14;16) and t(4;14), respectively. IGH translocations are also frequently seen in diffuse large B cell lymphoma (DLBCL). Probe type: Dual color breakapart

Organ: Skin & Mucosa

Disease State: B Cell Non-Hodgkin Lymphoma (not otherwise classified)

CPT Code(s): 88374 (reference only; CPTs may vary)

Turnaround Time: Within 4-6 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Peripheral blood, Preferred: 3 ml in sodium heparin (green top) / Acceptable: 3 ml in EDTA (purple top) - OR - • Bone marrow aspirate, Preferred: 1-2 ml in sodium heparin (green top) / Acceptable: 1-2 ml in EDTA (purple top) - OR - • Fresh tissue in RPMI - OR - • Formalin-fixed, paraffin-embedded tissue (FFPE)