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Keratin 5 pin


Keratin 5

Alternate Test Names:
Cytokeratin 5; CK5-XM26

Methodology: IHC

Clinical Significance:
Identifies squamous and transitional cell epithelia, mesothelium, ductal epithelium and their corresponding carcinomas. In complex epithelia such as normal prostate glands, the basal cells in most cases express CK5. CK5 expression can also be seen in some nonsquamous carcinomas, e.g., pancreatic adenocarcinoma.

Subcellular Localization: Cytoplasmic

Organ: Breast, Genitourinary, Lung, Prostate

Disease State: Adenocarcinoma, Breast Cancer, Carcinomas of Unknown Primary, Mesothelioma vs. Adenocarcinoma, Non Small Cell Lung Carcinoma (NSCLC), Spindle Cell Tumors / Sarcoma Subtyping

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm

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