Alternate Test Names:
Cytokeratins (AE1/AE3); AE1AE3

Methodology: IHC

Clinical Significance:
Identifies many members of the cytokeratin group of cytoskeletal proteins. AE1/AE3 is a cocktail of two monoclonal antibodies to non-overlapping groups of cytokeratins that are expressed in a wide range of epithelial tumors. Cytokeratin expression can identify carcinomas in the context of undifferentiated malignancies, although cytokeratins (generally at lower levels) can be expressed in a restricted subset of non-epithelial tumors (e.g., melanoma, smooth muscle tumors, etc.)

Subcellular Localization: Cytoplasmic

Organ:

Disease State: Large Cell Undifferentiated Malignant Neoplams

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm