Methodology: IHC

Clinical Significance:
Identifies many members of the cytokeratin group of cytoskeletal proteins. AE1/AE3 is a cocktail of two monoclonal antibodies to non-overlapping groups of cytokeratins that are expressed in a wide range of epithelial tumors. Cytokeratin expression can identify carcinomas in the context of undifferentiated malignancies, although cytokeratins (generally at lower levels) can be expressed in a restricted subset of non-epithelial tumors (e.g., melanoma, smooth muscle tumors, etc.) Subcellular Localization: Cytoplasmic

Organ:

Disease State: Large Cell Undifferentiated Malignant Neoplams

CPT Code(s): 88342 or 88341. The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR - • 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm