Keratins (OSCAR) pin

IHC

Keratins (OSCAR)

Alternate Test Names:
Cytokeratins (OSCAR)

Methodology: IHC

Clinical Significance:
Identifies many members of the cytokeratin group of cytoskeletal proteins. Very similar pattern of reactivity compared with the AE1/AE3 antibody cocktail. However, as a single monoclonal antibody, it has advantages over the AE1/AE3 antibody cocktail. It can thus be employed to identify carcinomas in the context of undifferentiated malignancies. Cytokeratin expression can identify carcinomas in the context of undifferentiated malignancies, although cytokeratins (generally at lower levels) can be expressed in a restricted subset of non-epithelial tumors (e.g., melanoma, smooth muscle tumors, etc.).

Subcellular Localization: Cytoplasmic

Organ: Genitourinary, Lung, Ovary, Testis

Disease State: Carcinomas of Unknown Primary, Germ Cell Tumors, Large Cell Undifferentiated Malignant Neoplams, Mesothelioma vs. Adenocarcinoma, Small, Blue, Round Cell Tumors, Spindle Cell Tumors / Sarcoma Subtyping

CPT Code(s): 88342 or 88341 (reference only; CPTs may vary)

Turnaround Time: Within 1-2 business days of receipt

Schedule: Monday - Friday

Specimen Requirements:
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR -
• 1 unstained slide for each test requested plus 3-4 additional unstained slides cut at 4µm

Tech Only